With so much fanfare, it’s easy to ignore the fact that CBD is a potent compound that's far from exhaustively understood. The market for CBD products is predicted to pass $22 billion over the next four years, and that's coming with the expected hurricane of fact-obscuring hype. There are several studies about grapefruit and statin interaction, and recent ones suggest that moderate grapefruit consumption can be compatible with taking lovastatin and other statin drugs. And it’s important to check with your doctor before taking CBD, especially if you’re taking other medications. In fact, studies have shown greater reductions in. Rather, grapefruit seems to boost statins’ power to act on the body, while also potentially boosting its side effects. This is not the case with grapefruit and statins. But since the compound appears to exert similar effects as grapefruit, caution is needed.Īt a minimum, the evidence at this point suggests that grapefruit warnings on medications should also apply to CBD. For some medications, grapefruit interactions make the drug less effective at treating your underlying medical condition. One of the big problems with CBD at the moment is we don’t really know yet which drugs are affected the most, and it’s difficult to identify exact levels of risk because the research has a lot of catching up to do after decades of science-blocking illegality. Drugs with a narrow “therapeutic window” (they must stay within a certain blood-concentration range) are especially susceptible.

CBD competes with atorvastatin for metabolism through this enzyme. CBD and atorvastatin are both metabolized in the liver by the same enzyme (CYP3A4). A high dose of a med could become a dangerously high dose, or even an overdose. Interaction 1: Slowed Elimination (Metabolic competition) The main interaction between CBD and atorvastatin takes place in the liver. The enzymes that both grapefruit and CBD inhibit are thought to break down a significant percentage of prescription and over-the-counter medications, so the potential for problems could be high.Ī low dose of a med could become a high dose if it’s not properly broken down and eliminated.

Statins and grapefruit interactions